a tool for identifying drug-targetable redox-active disulphides

Complement inhibitor RaCI1

Intermolecular

Cysteine 1101 of Complement C5 and cysteine 59

A redox-regulated disulphide may form between cysteine 1101 of Complement C5 and cysteine 59 of Complement inhibitor RaCI1 (1101 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

structure of human complement c5 complexed with tick inhibitors omci, raci1 and cirpt1

Structure deposition date

2019-05-15

Thiol separation (Å)

9

Half-sphere exposure sum ?

78

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Complement C5

Peptide B name

Complement inhibitor RaCI1

Peptide A accession

Peptide B accession

Peptide A residue number

1101

Peptide B residue number

59

Ligandability

Cysteine 1101 of Complement C5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Complement inhibitor RaCI1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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